Innate immune recognition of microbial cell wall components and microbial strategies to evade such recognitions
نویسندگان
چکیده
منابع مشابه
The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components.
As a pattern recognition receptor, TLR1 mediates innate immune responses to a variety of microbial cell wall components including bacterial lipoproteins. We have previously shown that the central region of the extracellular domain of human TLR1, comprising leucine-rich repeat (LRR) motifs 9-12, is required for the sensing of bacterial lipopeptides. In this study, we have investigated three nons...
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guidance and valuable scientific support during the last years, for her never ending confidence in my work and for reading my manuscripts. I thank Prof. Dr. Albrecht Wendel for welcoming me into the group, for his interest in my project and for his commitment to the " Graduiertenkolleg IRTG 1331 ". I would like to express my gratitude to the members of my thesis committee, PD Dr. for lending me...
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Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). By contrast, inappropriate activation of PRRs by self nucleic acids can lead to autoimmunity. Recent developments in PRR research have uncovered important new molecular detail...
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The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the ...
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Candida albicans is able to proliferate in environments that vary dramatically in ambient pH, a trait required for colonising niches such as the stomach, vaginal mucosal and the GI tract. Here we show that growth in acidic environments involves cell wall remodelling which results in enhanced chitin and β-glucan exposure at the cell wall periphery. Unmasking of the underlying immuno-stimulatory ...
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ژورنال
عنوان ژورنال: Microbiological Research
سال: 2013
ISSN: 0944-5013
DOI: 10.1016/j.micres.2013.02.005